Key Features:
1. Strong Cation Exchange Mechanism
Functional Group: Bonded with aromatic sulfonic acid groups (-SO₃H), providing strong acidity and stable cation exchange capability across a wide pH range.
Retention Mechanism: Separates analytes based on ionic interactions. Cationic species (positively charged bases) are retained via exchange with the counter-ions on the stationary phase.
2. Specialized for Basic Compounds
Target Analytes: Excellent selectivity for basic and water-soluble compounds that are often difficult to retain on reversed-phase columns (like C18) without ion-pairing reagents.
Peak Shape: Minimizes peak tailing commonly associated with basic compounds on silica-based columns.
3. Versatile Applications
Ideal for the separation of organic bases, including alkaline amino acids, anilines, pharmaceutical salts, and nucleotides.
Technical Specifications:
| Model | AY-G-SCX |
| Bonded phase | Sulfonic acid group |
| Particle size (μm) | 3，5 | 5 |
| Pore size (Å) | 120 | 300 |
| Specific surface area (m²/g) | 320 | 90 |
| Carbon load (%) | 12 | 5 |
| Endcapping | no |
|
| pH range | 2.0~8.0 |
|
| USP classification | L9 |
|
Application:
Biochemistry: Separation of alkaline amino acids (e.g., Lys, Arg, His) and nucleotides.
Pharmaceuticals: Analysis of pharmaceutical salts, basic drug molecules, and their impurities.
Chemical Industry: Separation of organic bases such as aniline derivatives and water-soluble dyes.
