Instrument selection guide
Instrument selection guide
First, the overall introduction of the system
When the preparation column of more than 100mm needs to be filled, the general axial compression technology cannot meet the high separation requirements, and the dynamic axial compression technology (DAC) can only be used. Dynamic axial compression technology through the movement of the piston to load, maintain and relieve the pressure of the column, the piston is equipped with a special design of the seal ring around the piston can allow the piston to slide freely up and down, and keep a high seal pressure. The piston movement and pressure are maintained by hydraulic pressure, and the hydraulic power is more stable and more uniform than the spring power of the axial compression column, which makes the separation effect better, and the column with a large diameter (50mm-300mm) can be loaded and the separation effect is comparable to that of the analysis column.
The system consists of an infusion unit (2 LC500P (0-200ml/min) infusion pumps), a detection unit (1 UVD500 variable wavelength UV detector, arbitrarily selected in the range of 190-700nm), a preparation unit (DAC-100 dynamic axial phase column), and a workstation (WOOK chromatographic workstation).
Table 1: Configuration sheet for binary preparative liquid chromatography system
Second, performance characteristics
1.Using static motor control circuit technology design, to achieve the motor control signal automatic feedback tracking function, effectively improve motor control
2. Accuracy to ensure the reliability and stability of the pump
3.pump form: double plunger reciprocating series or parallel optional
4.floating self-correcting sealing ring technology and pump head self-cleaning function can extend the service life of the sealing ring, ensure the instrument durability and high efficiency, online piston seal cleaning
5.Easy to use flow and pressure correction function to ensure high accuracy and stability of the instrument
6 .uses two gradients to run the program design: linear gradient and step gradient are optional
7.gradient mode: internal gradient, binary gradient;
8. can be designed according to user requirements, in accordance with cGMP specifications, for pilot/production systems, provide explosion-proof design, and can add special safety warning devices
9.DAC dynamic axial chromatography column: saturation test, static saturation, 30 minutes of column pressure drop value of not more than 5Bar without dynamic piston;
10. cylinder head piston, two sets of sealing rings triple seal, guide seal, scraping seal column efficiency, 10um spherical packing column efficiency are above 50000plate/m (toluene as sample, 80%ACN and 20% water (volume ratio) as mobile phase)
11.can complete the function of single column alternating adsorption separation and preparation and purification
12.can meet the method development, semi-preparation, gram preparation, pilot test, production scale of a variety of applications, is the most widely used preparative liquid chromatography system on the market
13. Instrument control: internal and external control swap mode
14.System materials include: stainless steel, titanium steel and PEEK, can be selected according to the application, ideal for pharmaceutical and biotechnology industry applications
15.A variety of columns for linear amplification are available for preparation of column loaders and sample collection devices
16.Automatic fraction collector: Realize automatic collection of components according to the component peak
Table 2: Basic technical parameters of LC500P preparation pump
Table 3: Technical parameters of UVD500 series UV detector
Table 4: DAC100 dynamic axial column technical parameters
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